Systematic review conducted in January, 2019 included 38 studies representing 58,256 participants, with up to 27 studies included in random-effects meta-analysis. Standardized Fisher transformations of the correlation/beta coefficients, both unadjusted and adjusted for covariates, were extracted from studies examining the prospective associations of depression and inflammatory biomarkers. The review, registered with PROSPERO, searched for published and unpublished studies via MEDLINE/PsycINFO/PsycARTICLES/EMBASE/Proquest Dissertation. We investigated the prospective associations of depression and inflammatory biomarkers in community samples, both unadjusted and adjusted for covariates. The innate immune system is dysregulated in depression however, less is known about the longitudinal associations of depression and inflammatory biomarkers.
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